Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Identifieur interne : 003911 ( Main/Exploration ); précédent : 003910; suivant : 003912Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Auteurs : Pirro G. Hysi [Royaume-Uni] ; Ching-Yu Cheng [Singapour] ; Henriët Springelkamp [Pays-Bas] ; Stuart Macgregor ; Jessica N Cooke Bailey [États-Unis] ; Robert Wojciechowski [États-Unis] ; Veronique Vitart [Royaume-Uni] ; Abhishek Nag [Royaume-Uni] ; Alex W. Hewitt [Australie] ; René Höhn [Allemagne] ; Cristina Venturini [Royaume-Uni] ; Alireza Mirshahi [Allemagne] ; Wishal D. Ramdas [Pays-Bas] ; Gudmar Thorleifsson [Islande] ; Eranga Vithana [Singapour] ; Chiea-Chuen Khor [Singapour] ; Arni B. Stefansson [Islande] ; Jiemin Liao [Singapour] ; Jonathan L. Haines [États-Unis] ; Najaf Amin [Pays-Bas] ; Ya Xing Wang ; Philipp S. Wild [Allemagne] ; Ayse B. Ozel [États-Unis] ; Jun Z. Li [États-Unis] ; Brian W. Fleck [Royaume-Uni] ; Tanja Zeller [Allemagne] ; Sandra E. Staffieri [Australie] ; Yik-Ying Teo [Singapour] ; Gabriel Cuellar-Partida ; Xiaoyan Luo [États-Unis] ; R Rand Allingham [États-Unis] ; Julia E. Richards [Pays-Bas] ; Andrea Senft [Allemagne] ; Lennart C. Karssen [Pays-Bas] ; Yingfeng Zheng [Singapour] ; Céline Bellenguez [France] ; Liang Xu ; Adriana I. Iglesias [Pays-Bas] ; James F. Wilson [Royaume-Uni] ; Jae H. Kang [États-Unis] ; Elisabeth M. Van Leeuwen [Pays-Bas] ; Vesteinn Jonsson [Islande] ; Unnur Thorsteinsdottir [Islande] ; Dominiek D. G. Despriet [Pays-Bas] ; Sarah Ennis [Royaume-Uni] ; Sayoko E. Moroi [États-Unis] ; Nicholas G. Martin [Australie] ; Nomdo M. Jansonius [Pays-Bas] ; Seyhan Yazar [Australie] ; E-Shyong Tai [Singapour] ; Philippe Amouyel [Allemagne, France] ; James Kirwan [Royaume-Uni] ; Leonieke M. E. Van Koolwijk [Pays-Bas] ; Michael A. Hauser [États-Unis] ; Fridbert Jonasson [Islande] ; Paul Leo [Australie] ; Stephanie J. Loomis [États-Unis] ; Rhys Fogarty [Australie] ; Fernando Rivadeneira [Pays-Bas] ; Lisa Kearns [Australie] ; Karl J. Lackner [Allemagne] ; Paulus T. V. M. De Jong [Pays-Bas] ; Claire L. Simpson [États-Unis] ; Craig E. Pennell [Australie] ; Ben A. Oostra [Pays-Bas] ; André G. Uitterlinden [Pays-Bas] ; Seang-Mei Saw [Singapour] ; Andrew J. Lotery [Royaume-Uni] ; Joan E. Bailey-Wilson [États-Unis] ; Albert Hofman [Pays-Bas] ; Johannes R. Vingerling [Pays-Bas] ; Cécilia Maubaret [France] ; Norbert Pfeiffer [Allemagne] ; Roger C. W. Wolfs [Pays-Bas] ; Hans G. Lemij [Pays-Bas] ; Terri L. Young [États-Unis] ; Louis R. Pasquale [États-Unis] ; Cécile Delcourt [France] ; Timothy D. Spector [Royaume-Uni] ; Caroline C. W. Klaver [Pays-Bas] ; Kerrin S. Small [Royaume-Uni] ; Kathryn P. Burdon [Australie] ; Kari Stefansson [Islande] ; Tien-Yin Wong [Singapour] ; Ananth Viswanathan [Royaume-Uni] ; David A. Mackey [Australie] ; Jamie E. Craig [Australie] ; Janey L. Wiggs [États-Unis] ; Cornelia M. Van Duijn [Pays-Bas] ; Christopher J. Hammond [Royaume-Uni] ; Tin Aung [Singapour]Source :
- Nature genetics [ 1061-4036 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Chromosomes humains de la paire 11 (génétique), Chromosomes humains de la paire 3 (génétique), Chromosomes humains de la paire 9 (génétique), Facteurs de risque, Femelle, Fibronectines (génétique), Glaucome (génétique), Glaucome à angle ouvert (génétique), Génotype, Humains, Jeune adulte, Locus génétiques (génétique), Mâle, Méta-analyse comme sujet, Polymorphisme de nucléotide simple, Pression intraoculaire (génétique), Prédisposition génétique à une maladie (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Système ABO de groupes sanguins (génétique), Transporteur-1 à cassette liant l'ATP (génétique), Étude d'association pangénomique, Études de cohortes.
- MESH :
- génétique : Chromosomes humains de la paire 11, Chromosomes humains de la paire 3, Chromosomes humains de la paire 9, Fibronectines, Glaucome, Glaucome à angle ouvert, Locus génétiques, Pression intraoculaire, Prédisposition génétique à une maladie, Système ABO de groupes sanguins, Transporteur-1 à cassette liant l'ATP.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Génotype, Humains, Jeune adulte, Mâle, Méta-analyse comme sujet, Polymorphisme de nucléotide simple, Sujet âgé, Sujet âgé de 80 ans ou plus, Étude d'association pangénomique, Études de cohortes.
English descriptors
- KwdEn :
- ABO Blood-Group System (genetics), ATP Binding Cassette Transporter 1 (genetics), Adult, Aged, Aged, 80 and over, Chromosomes, Human, Pair 11 (genetics), Chromosomes, Human, Pair 3 (genetics), Chromosomes, Human, Pair 9 (genetics), Cohort Studies, Female, Fibronectins (genetics), Genetic Loci (genetics), Genetic Predisposition to Disease (genetics), Genome-Wide Association Study, Genotype, Glaucoma (genetics), Glaucoma, Open-Angle (genetics), Humans, Intraocular Pressure (genetics), Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Young Adult.
- MESH :
- chemical , genetics : ABO Blood-Group System, ATP Binding Cassette Transporter 1, Fibronectins.
- genetics : Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 9, Genetic Loci, Genetic Predisposition to Disease, Glaucoma, Glaucoma, Open-Angle, Intraocular Pressure.
- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Genome-Wide Association Study, Genotype, Humans, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Young Adult.
Abstract
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma and IOP variability may herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multiethnic participants for IOP. We confirm genetic association of known loci for IOP and primary open angle glaucoma (POAG) and identify four new IOP loci located on chromosome 3q25.31 within the
Url:
DOI: 10.1038/ng.3087
PubMed: 25173106
PubMed Central: 4177225
Affiliations:
- Allemagne, Australie, France, Islande, Pays-Bas, Royaume-Uni, Singapour, États-Unis
- Angleterre, Aquitaine, Caroline du Nord, Grand Londres, Hauts-de-France, Hollande-Méridionale, Hollande-Septentrionale, Maryland, Massachusetts, Michigan, Nord-Pas-de-Calais, Nouvelle-Aquitaine, Ohio, Rhénanie-Palatinat, Victoria (État), Écosse
- Amsterdam, Bordeaux, Leyde, Lille, Londres, Mayence, Melbourne, Rotterdam, Édimbourg
- University College de Londres, Université Lille 2, Université de Melbourne, Université nationale de Singapour
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Le document en format XML
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Ramdas</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><nlm:aff id="A16">deCODE/Amgen, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Duke-National University of Singapore, Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore, Graduate Medical School</wicri:regionArea><wicri:noRegion>Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Division of Human Genetics, Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore</wicri:regionArea><wicri:noRegion>Genome Institute of Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Arni B" sort="Stefansson, Arni B" uniqKey="Stefansson A" first="Arni B" last="Stefansson">Arni B. Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A18">Eye Clinic, 105 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Eye Clinic, 105 Reykjavik</wicri:regionArea><wicri:noRegion>105 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Liao, Jiemin" sort="Liao, Jiemin" uniqKey="Liao J" first="Jiemin" last="Liao">Jiemin Liao</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name><affiliation><nlm:aff id="A19">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730</nlm:aff><wicri:noCountry code="subfield">China 100730</wicri:noCountry></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation wicri:level="3"><nlm:aff id="A20">Department of Internal Medicine II, University Medical Center Mainz, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, University Medical Center Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Ozel, Ayse B" sort="Ozel, Ayse B" uniqKey="Ozel A" first="Ayse B" last="Ozel">Ayse B. Ozel</name><affiliation wicri:level="2"><nlm:aff id="A21">Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Li, Jun Z" sort="Li, Jun Z" uniqKey="Li J" first="Jun Z" last="Li">Jun Z. Li</name><affiliation wicri:level="2"><nlm:aff id="A21">Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Fleck, Brian W" sort="Fleck, Brian W" uniqKey="Fleck B" first="Brian W" last="Fleck">Brian W. Fleck</name><affiliation wicri:level="3"><nlm:aff id="A22">NHS Princess Alexandra Eye Pavilion, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Princess Alexandra Eye Pavilion, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation wicri:level="1"><nlm:aff id="A23">Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for General and Interventional Cardiology, University Heart Center Hamburg</wicri:regionArea><wicri:noRegion>University Heart Center Hamburg</wicri:noRegion><wicri:noRegion>University Heart Center Hamburg</wicri:noRegion><wicri:noRegion>University Heart Center Hamburg</wicri:noRegion></affiliation></author><author><name sortKey="Staffieri, Sandra E" sort="Staffieri, Sandra E" uniqKey="Staffieri S" first="Sandra E" last="Staffieri">Sandra E. Staffieri</name><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A24">Department of Statistics and Applied Probability, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Statistics and Applied Probability, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Cuellar Partida, Gabriel" sort="Cuellar Partida, Gabriel" uniqKey="Cuellar Partida G" first="Gabriel" last="Cuellar-Partida">Gabriel Cuellar-Partida</name><affiliation><nlm:aff id="A8">Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029</nlm:aff><wicri:noCountry code="subfield">Australia 4029</wicri:noCountry></affiliation></author><author><name sortKey="Luo, Xiaoyan" sort="Luo, Xiaoyan" uniqKey="Luo X" first="Xiaoyan" last="Luo">Xiaoyan Luo</name><affiliation wicri:level="2"><nlm:aff id="A25">Duke University, Duke Eye Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University, Duke Eye Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name><affiliation wicri:level="2"><nlm:aff id="A26">Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Senft, Andrea" sort="Senft, Andrea" uniqKey="Senft A" first="Andrea" last="Senft">Andrea Senft</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Karssen, Lennart C" sort="Karssen, Lennart C" uniqKey="Karssen L" first="Lennart C" last="Karssen">Lennart C. Karssen</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zheng, Yingfeng" sort="Zheng, Yingfeng" uniqKey="Zheng Y" first="Yingfeng" last="Zheng">Yingfeng Zheng</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation wicri:level="3"><nlm:aff id="A28">Inserm, UMR774, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, UMR774, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A29">Université Lille 2, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A30">Institut Pasteur de Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name><affiliation><nlm:aff id="A19">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730</nlm:aff><wicri:noCountry code="subfield">China 100730</wicri:noCountry></affiliation></author><author><name sortKey="Iglesias, Adriana I" sort="Iglesias, Adriana I" uniqKey="Iglesias A" first="Adriana I" last="Iglesias">Adriana I. Iglesias</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation wicri:level="3"><nlm:aff id="A31">Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name><affiliation wicri:level="2"><nlm:aff id="A32">Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Van Leeuwen, Elisabeth M" sort="Van Leeuwen, Elisabeth M" uniqKey="Van Leeuwen E" first="Elisabeth M" last="Van Leeuwen">Elisabeth M. Van Leeuwen</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jonsson, Vesteinn" sort="Jonsson, Vesteinn" uniqKey="Jonsson V" first="Vesteinn" last="Jonsson">Vesteinn Jonsson</name><affiliation wicri:level="1"><nlm:aff id="A33">Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="A16">deCODE/Amgen, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Despriet, Dominiek D G" sort="Despriet, Dominiek D G" uniqKey="Despriet D" first="Dominiek D. G." last="Despriet">Dominiek D. G. Despriet</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name><affiliation wicri:level="1"><nlm:aff id="A34">Human Genetics & Genomic Medicine, Faulty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Genetics & Genomic Medicine, Faulty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name><affiliation wicri:level="2"><nlm:aff id="A35">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A36">Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Jansonius, Nomdo M" sort="Jansonius, Nomdo M" uniqKey="Jansonius N" first="Nomdo M" last="Jansonius">Nomdo M. Jansonius</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Ophthalmology, University Medical Center Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Groningen</wicri:regionArea><wicri:noRegion>University Medical Center Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name><affiliation wicri:level="1"><nlm:aff id="A38">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Duke-National University of Singapore, Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore, Graduate Medical School</wicri:regionArea><wicri:noRegion>Graduate Medical School</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Medicine, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Inserm, UMR774, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, UMR774, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A29">Université Lille 2, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">Centre Hospitalier Régional Universitaire de Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille</wicri:regionArea></affiliation></author><author><name sortKey="Kirwan, James" sort="Kirwan, James" uniqKey="Kirwan J" first="James" last="Kirwan">James Kirwan</name><affiliation wicri:level="1"><nlm:aff id="A41">Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth</wicri:regionArea><wicri:noRegion>Portsmouth</wicri:noRegion></affiliation></author><author><name sortKey="Van Koolwijk, Leonieke M E" sort="Van Koolwijk, Leonieke M E" uniqKey="Van Koolwijk L" first="Leonieke M. E." last="Van Koolwijk">Leonieke M. E. Van Koolwijk</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation wicri:level="2"><nlm:aff id="A26">Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A42">Department of Medicine, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Jonasson, Fridbert" sort="Jonasson, Fridbert" uniqKey="Jonasson F" first="Fridbert" last="Jonasson">Fridbert Jonasson</name><affiliation wicri:level="1"><nlm:aff id="A43">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name><affiliation wicri:level="1"><nlm:aff id="A44">The University of Queensland, Diamantina Institute, Woollongabba, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Queensland, Diamantina Institute, Woollongabba</wicri:regionArea><wicri:noRegion>Woollongabba</wicri:noRegion></affiliation></author><author><name sortKey="Loomis, Stephanie J" sort="Loomis, Stephanie J" uniqKey="Loomis S" first="Stephanie J" last="Loomis">Stephanie J. Loomis</name><affiliation wicri:level="2"><nlm:aff id="A45">Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fogarty, Rhys" sort="Fogarty, Rhys" uniqKey="Fogarty R" first="Rhys" last="Fogarty">Rhys Fogarty</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Ophthalmology, Flinders University, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A47">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague</wicri:regionArea><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Kearns, Lisa" sort="Kearns, Lisa" uniqKey="Kearns L" first="Lisa" last="Kearns">Lisa Kearns</name><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Lackner, Karl J" sort="Lackner, Karl J" uniqKey="Lackner K" first="Karl J" last="Lackner">Karl J. Lackner</name><affiliation wicri:level="3"><nlm:aff id="A49">Institute of Clinical Chemistry and Laboratory Medicine, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Chemistry and Laboratory Medicine, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="De Jong, Paulus T V M" sort="De Jong, Paulus T V M" uniqKey="De Jong P" first="Paulus T. V. M." last="De Jong">Paulus T. V. M. De Jong</name><affiliation wicri:level="3"><nlm:aff id="A50">Netherlands Institute for Neuroscience, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Institute for Neuroscience, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A51">Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A52">Department of Ophthalmology, Academic Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Simpson, Claire L" sort="Simpson, Claire L" uniqKey="Simpson C" first="Claire L" last="Simpson">Claire L. Simpson</name><affiliation wicri:level="2"><nlm:aff id="A11">National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name><affiliation wicri:level="1"><nlm:aff id="A53">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation wicri:level="3"><nlm:aff id="A54">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A47">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague</wicri:regionArea><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Duke-National University of Singapore, Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore, Graduate Medical School</wicri:regionArea><wicri:noRegion>Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name><affiliation wicri:level="1"><nlm:aff id="A55">Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Bailey Wilson, Joan E" sort="Bailey Wilson, Joan E" uniqKey="Bailey Wilson J" first="Joan E" last="Bailey-Wilson">Joan E. Bailey-Wilson</name><affiliation wicri:level="2"><nlm:aff id="A11">National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague</wicri:regionArea><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Vingerling, Johannes R" sort="Vingerling, Johannes R" uniqKey="Vingerling J" first="Johannes R" last="Vingerling">Johannes R. Vingerling</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Maubaret, Cecilia" sort="Maubaret, Cecilia" uniqKey="Maubaret C" first="Cécilia" last="Maubaret">Cécilia Maubaret</name><affiliation wicri:level="3"><nlm:aff id="A56">Univ. Bordeaux, ISPED, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:regionArea><wicri:noRegion>Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:noRegion><wicri:noRegion>Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name><affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Wolfs, Roger C W" sort="Wolfs, Roger C W" uniqKey="Wolfs R" first="Roger C. W." last="Wolfs">Roger C. W. Wolfs</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Lemij, Hans G" sort="Lemij, Hans G" uniqKey="Lemij H" first="Hans G" last="Lemij">Hans G. Lemij</name><affiliation wicri:level="3"><nlm:aff id="A58">Glaucoma Service, the Rotterdam Eye Hospital, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Glaucoma Service, the Rotterdam Eye Hospital, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name><affiliation wicri:level="2"><nlm:aff id="A25">Duke University, Duke Eye Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University, Duke Eye Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="2"><nlm:aff id="A32">Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A45">Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Delcourt, Cecile" sort="Delcourt, Cecile" uniqKey="Delcourt C" first="Cécile" last="Delcourt">Cécile Delcourt</name><affiliation wicri:level="3"><nlm:aff id="A56">Univ. Bordeaux, ISPED, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:regionArea><wicri:noRegion>Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:noRegion><wicri:noRegion>Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Twin Research and Genetic Epidemiology, King’s College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London</wicri:regionArea><wicri:noRegion>King’s College London</wicri:noRegion></affiliation></author><author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C. W." last="Klaver">Caroline C. W. Klaver</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S" last="Small">Kerrin S. Small</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Twin Research and Genetic Epidemiology, King’s College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London</wicri:regionArea><wicri:noRegion>King’s College London</wicri:noRegion></affiliation></author><author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P" last="Burdon">Kathryn P. Burdon</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Ophthalmology, Flinders University, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A16">deCODE/Amgen, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author><author><name sortKey="Viswanathan, Ananth" sort="Viswanathan, Ananth" uniqKey="Viswanathan A" first="Ananth" last="Viswanathan">Ananth Viswanathan</name><affiliation wicri:level="3"><nlm:aff id="A60">NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Ophthalmology, Flinders University, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="2"><nlm:aff id="A45">Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Twin Research and Genetic Epidemiology, King’s College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London</wicri:regionArea><wicri:noRegion>King’s College London</wicri:noRegion></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25173106</idno><idno type="pmc">4177225</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177225</idno><idno type="RBID">PMC:4177225</idno><idno type="doi">10.1038/ng.3087</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002E36</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E36</idno><idno type="wicri:Area/Pmc/Curation">002C86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C86</idno><idno type="wicri:Area/Pmc/Checkpoint">001565</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001565</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003390</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003390</idno><idno type="wicri:Area/PubMed/Curation">003278</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003278</idno><idno type="wicri:Area/PubMed/Checkpoint">003278</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003278</idno><idno type="wicri:Area/Ncbi/Merge">001D56</idno><idno type="wicri:Area/Ncbi/Curation">001D56</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D56</idno><idno type="wicri:doubleKey">1061-4036:2014:Hysi P:genome:wide:analysis</idno><idno type="wicri:Area/Main/Merge">003947</idno><idno type="wicri:Area/Main/Curation">003911</idno><idno type="wicri:Area/Main/Exploration">003911</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma</title><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Twin Research and Genetic Epidemiology, King’s College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London</wicri:regionArea><wicri:noRegion>King’s College London</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Duke-National University of Singapore, Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore, Graduate Medical School</wicri:regionArea><wicri:noRegion>Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Springelkamp, Henriet" sort="Springelkamp, Henriet" uniqKey="Springelkamp H" first="Henriët" last="Springelkamp">Henriët Springelkamp</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation><nlm:aff id="A8">Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029</nlm:aff><wicri:noCountry code="subfield">Australia 4029</wicri:noCountry></affiliation></author><author><name sortKey="Bailey, Jessica N Cooke" sort="Bailey, Jessica N Cooke" uniqKey="Bailey J" first="Jessica N Cooke" last="Bailey">Jessica N Cooke Bailey</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Wojciechowski, Robert" sort="Wojciechowski, Robert" uniqKey="Wojciechowski R" first="Robert" last="Wojciechowski">Robert Wojciechowski</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A11">National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="3"><nlm:aff id="A12">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><wicri:orgArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</wicri:orgArea></affiliation></author><author><name sortKey="Nag, Abhishek" sort="Nag, Abhishek" uniqKey="Nag A" first="Abhishek" last="Nag">Abhishek Nag</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Twin Research and Genetic Epidemiology, King’s College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London</wicri:regionArea><wicri:noRegion>King’s College London</wicri:noRegion></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hohn, Rene" sort="Hohn, Rene" uniqKey="Hohn R" first="René" last="Höhn">René Höhn</name><affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Twin Research and Genetic Epidemiology, King’s College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London</wicri:regionArea><wicri:noRegion>King’s College London</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A15">Institute of Ophthalmology, University College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Ophthalmology, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mirshahi, Alireza" sort="Mirshahi, Alireza" uniqKey="Mirshahi A" first="Alireza" last="Mirshahi">Alireza Mirshahi</name><affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Ramdas, Wishal D" sort="Ramdas, Wishal D" uniqKey="Ramdas W" first="Wishal D." last="Ramdas">Wishal D. Ramdas</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><nlm:aff id="A16">deCODE/Amgen, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Duke-National University of Singapore, Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore, Graduate Medical School</wicri:regionArea><wicri:noRegion>Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Division of Human Genetics, Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore</wicri:regionArea><wicri:noRegion>Genome Institute of Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Arni B" sort="Stefansson, Arni B" uniqKey="Stefansson A" first="Arni B" last="Stefansson">Arni B. Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A18">Eye Clinic, 105 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Eye Clinic, 105 Reykjavik</wicri:regionArea><wicri:noRegion>105 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Liao, Jiemin" sort="Liao, Jiemin" uniqKey="Liao J" first="Jiemin" last="Liao">Jiemin Liao</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name><affiliation><nlm:aff id="A19">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730</nlm:aff><wicri:noCountry code="subfield">China 100730</wicri:noCountry></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation wicri:level="3"><nlm:aff id="A20">Department of Internal Medicine II, University Medical Center Mainz, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, University Medical Center Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Ozel, Ayse B" sort="Ozel, Ayse B" uniqKey="Ozel A" first="Ayse B" last="Ozel">Ayse B. Ozel</name><affiliation wicri:level="2"><nlm:aff id="A21">Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Li, Jun Z" sort="Li, Jun Z" uniqKey="Li J" first="Jun Z" last="Li">Jun Z. Li</name><affiliation wicri:level="2"><nlm:aff id="A21">Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Fleck, Brian W" sort="Fleck, Brian W" uniqKey="Fleck B" first="Brian W" last="Fleck">Brian W. Fleck</name><affiliation wicri:level="3"><nlm:aff id="A22">NHS Princess Alexandra Eye Pavilion, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Princess Alexandra Eye Pavilion, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation wicri:level="1"><nlm:aff id="A23">Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for General and Interventional Cardiology, University Heart Center Hamburg</wicri:regionArea><wicri:noRegion>University Heart Center Hamburg</wicri:noRegion><wicri:noRegion>University Heart Center Hamburg</wicri:noRegion><wicri:noRegion>University Heart Center Hamburg</wicri:noRegion></affiliation></author><author><name sortKey="Staffieri, Sandra E" sort="Staffieri, Sandra E" uniqKey="Staffieri S" first="Sandra E" last="Staffieri">Sandra E. Staffieri</name><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A24">Department of Statistics and Applied Probability, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Statistics and Applied Probability, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Cuellar Partida, Gabriel" sort="Cuellar Partida, Gabriel" uniqKey="Cuellar Partida G" first="Gabriel" last="Cuellar-Partida">Gabriel Cuellar-Partida</name><affiliation><nlm:aff id="A8">Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029</nlm:aff><wicri:noCountry code="subfield">Australia 4029</wicri:noCountry></affiliation></author><author><name sortKey="Luo, Xiaoyan" sort="Luo, Xiaoyan" uniqKey="Luo X" first="Xiaoyan" last="Luo">Xiaoyan Luo</name><affiliation wicri:level="2"><nlm:aff id="A25">Duke University, Duke Eye Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University, Duke Eye Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name><affiliation wicri:level="2"><nlm:aff id="A26">Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Senft, Andrea" sort="Senft, Andrea" uniqKey="Senft A" first="Andrea" last="Senft">Andrea Senft</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Karssen, Lennart C" sort="Karssen, Lennart C" uniqKey="Karssen L" first="Lennart C" last="Karssen">Lennart C. Karssen</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zheng, Yingfeng" sort="Zheng, Yingfeng" uniqKey="Zheng Y" first="Yingfeng" last="Zheng">Yingfeng Zheng</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation wicri:level="3"><nlm:aff id="A28">Inserm, UMR774, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, UMR774, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A29">Université Lille 2, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A30">Institut Pasteur de Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name><affiliation><nlm:aff id="A19">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730</nlm:aff><wicri:noCountry code="subfield">China 100730</wicri:noCountry></affiliation></author><author><name sortKey="Iglesias, Adriana I" sort="Iglesias, Adriana I" uniqKey="Iglesias A" first="Adriana I" last="Iglesias">Adriana I. Iglesias</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation wicri:level="3"><nlm:aff id="A31">Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name><affiliation wicri:level="2"><nlm:aff id="A32">Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Van Leeuwen, Elisabeth M" sort="Van Leeuwen, Elisabeth M" uniqKey="Van Leeuwen E" first="Elisabeth M" last="Van Leeuwen">Elisabeth M. Van Leeuwen</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jonsson, Vesteinn" sort="Jonsson, Vesteinn" uniqKey="Jonsson V" first="Vesteinn" last="Jonsson">Vesteinn Jonsson</name><affiliation wicri:level="1"><nlm:aff id="A33">Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="A16">deCODE/Amgen, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Despriet, Dominiek D G" sort="Despriet, Dominiek D G" uniqKey="Despriet D" first="Dominiek D. G." last="Despriet">Dominiek D. G. Despriet</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name><affiliation wicri:level="1"><nlm:aff id="A34">Human Genetics & Genomic Medicine, Faulty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Genetics & Genomic Medicine, Faulty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name><affiliation wicri:level="2"><nlm:aff id="A35">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A36">Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Jansonius, Nomdo M" sort="Jansonius, Nomdo M" uniqKey="Jansonius N" first="Nomdo M" last="Jansonius">Nomdo M. Jansonius</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Ophthalmology, University Medical Center Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Groningen</wicri:regionArea><wicri:noRegion>University Medical Center Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name><affiliation wicri:level="1"><nlm:aff id="A38">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Duke-National University of Singapore, Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore, Graduate Medical School</wicri:regionArea><wicri:noRegion>Graduate Medical School</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Medicine, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Inserm, UMR774, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, UMR774, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A29">Université Lille 2, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">Centre Hospitalier Régional Universitaire de Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille</wicri:regionArea></affiliation></author><author><name sortKey="Kirwan, James" sort="Kirwan, James" uniqKey="Kirwan J" first="James" last="Kirwan">James Kirwan</name><affiliation wicri:level="1"><nlm:aff id="A41">Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth</wicri:regionArea><wicri:noRegion>Portsmouth</wicri:noRegion></affiliation></author><author><name sortKey="Van Koolwijk, Leonieke M E" sort="Van Koolwijk, Leonieke M E" uniqKey="Van Koolwijk L" first="Leonieke M. E." last="Van Koolwijk">Leonieke M. E. Van Koolwijk</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation wicri:level="2"><nlm:aff id="A26">Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A42">Department of Medicine, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Jonasson, Fridbert" sort="Jonasson, Fridbert" uniqKey="Jonasson F" first="Fridbert" last="Jonasson">Fridbert Jonasson</name><affiliation wicri:level="1"><nlm:aff id="A43">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name><affiliation wicri:level="1"><nlm:aff id="A44">The University of Queensland, Diamantina Institute, Woollongabba, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Queensland, Diamantina Institute, Woollongabba</wicri:regionArea><wicri:noRegion>Woollongabba</wicri:noRegion></affiliation></author><author><name sortKey="Loomis, Stephanie J" sort="Loomis, Stephanie J" uniqKey="Loomis S" first="Stephanie J" last="Loomis">Stephanie J. Loomis</name><affiliation wicri:level="2"><nlm:aff id="A45">Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fogarty, Rhys" sort="Fogarty, Rhys" uniqKey="Fogarty R" first="Rhys" last="Fogarty">Rhys Fogarty</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Ophthalmology, Flinders University, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A47">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague</wicri:regionArea><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Kearns, Lisa" sort="Kearns, Lisa" uniqKey="Kearns L" first="Lisa" last="Kearns">Lisa Kearns</name><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Lackner, Karl J" sort="Lackner, Karl J" uniqKey="Lackner K" first="Karl J" last="Lackner">Karl J. Lackner</name><affiliation wicri:level="3"><nlm:aff id="A49">Institute of Clinical Chemistry and Laboratory Medicine, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Chemistry and Laboratory Medicine, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="De Jong, Paulus T V M" sort="De Jong, Paulus T V M" uniqKey="De Jong P" first="Paulus T. V. M." last="De Jong">Paulus T. V. M. De Jong</name><affiliation wicri:level="3"><nlm:aff id="A50">Netherlands Institute for Neuroscience, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Institute for Neuroscience, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A51">Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A52">Department of Ophthalmology, Academic Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Simpson, Claire L" sort="Simpson, Claire L" uniqKey="Simpson C" first="Claire L" last="Simpson">Claire L. Simpson</name><affiliation wicri:level="2"><nlm:aff id="A11">National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name><affiliation wicri:level="1"><nlm:aff id="A53">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation wicri:level="3"><nlm:aff id="A54">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A47">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague</wicri:regionArea><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Duke-National University of Singapore, Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore, Graduate Medical School</wicri:regionArea><wicri:noRegion>Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name><affiliation wicri:level="1"><nlm:aff id="A55">Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Bailey Wilson, Joan E" sort="Bailey Wilson, Joan E" uniqKey="Bailey Wilson J" first="Joan E" last="Bailey-Wilson">Joan E. Bailey-Wilson</name><affiliation wicri:level="2"><nlm:aff id="A11">National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague</wicri:regionArea><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Vingerling, Johannes R" sort="Vingerling, Johannes R" uniqKey="Vingerling J" first="Johannes R" last="Vingerling">Johannes R. Vingerling</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Maubaret, Cecilia" sort="Maubaret, Cecilia" uniqKey="Maubaret C" first="Cécilia" last="Maubaret">Cécilia Maubaret</name><affiliation wicri:level="3"><nlm:aff id="A56">Univ. Bordeaux, ISPED, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:regionArea><wicri:noRegion>Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:noRegion><wicri:noRegion>Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name><affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Wolfs, Roger C W" sort="Wolfs, Roger C W" uniqKey="Wolfs R" first="Roger C. W." last="Wolfs">Roger C. W. Wolfs</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Lemij, Hans G" sort="Lemij, Hans G" uniqKey="Lemij H" first="Hans G" last="Lemij">Hans G. Lemij</name><affiliation wicri:level="3"><nlm:aff id="A58">Glaucoma Service, the Rotterdam Eye Hospital, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Glaucoma Service, the Rotterdam Eye Hospital, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name><affiliation wicri:level="2"><nlm:aff id="A25">Duke University, Duke Eye Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University, Duke Eye Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="2"><nlm:aff id="A32">Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A45">Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Delcourt, Cecile" sort="Delcourt, Cecile" uniqKey="Delcourt C" first="Cécile" last="Delcourt">Cécile Delcourt</name><affiliation wicri:level="3"><nlm:aff id="A56">Univ. Bordeaux, ISPED, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:regionArea><wicri:noRegion>Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:noRegion><wicri:noRegion>Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Twin Research and Genetic Epidemiology, King’s College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London</wicri:regionArea><wicri:noRegion>King’s College London</wicri:noRegion></affiliation></author><author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C. W." last="Klaver">Caroline C. W. Klaver</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S" last="Small">Kerrin S. Small</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Twin Research and Genetic Epidemiology, King’s College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London</wicri:regionArea><wicri:noRegion>King’s College London</wicri:noRegion></affiliation></author><author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P" last="Burdon">Kathryn P. Burdon</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Ophthalmology, Flinders University, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A16">deCODE/Amgen, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author><author><name sortKey="Viswanathan, Ananth" sort="Viswanathan, Ananth" uniqKey="Viswanathan A" first="Ananth" last="Viswanathan">Ananth Viswanathan</name><affiliation wicri:level="3"><nlm:aff id="A60">NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Ophthalmology, Flinders University, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="2"><nlm:aff id="A45">Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Twin Research and Genetic Epidemiology, King’s College London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London</wicri:regionArea><wicri:noRegion>King’s College London</wicri:noRegion></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation wicri:level="1"><nlm:aff id="A2">Singapore Eye Research Institute, Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea><wicri:noRegion>Singapore National Eye Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, National University of Singapore and National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea><wicri:noRegion>National University of Singapore and National University Health System</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ABO Blood-Group System (genetics)</term><term>ATP Binding Cassette Transporter 1 (genetics)</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chromosomes, Human, Pair 11 (genetics)</term><term>Chromosomes, Human, Pair 3 (genetics)</term><term>Chromosomes, Human, Pair 9 (genetics)</term><term>Cohort Studies</term><term>Female</term><term>Fibronectins (genetics)</term><term>Genetic Loci (genetics)</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Glaucoma (genetics)</term><term>Glaucoma, Open-Angle (genetics)</term><term>Humans</term><term>Intraocular Pressure (genetics)</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Chromosomes humains de la paire 11 (génétique)</term><term>Chromosomes humains de la paire 3 (génétique)</term><term>Chromosomes humains de la paire 9 (génétique)</term><term>Facteurs de risque</term><term>Femelle</term><term>Fibronectines (génétique)</term><term>Glaucome (génétique)</term><term>Glaucome à angle ouvert (génétique)</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Locus génétiques (génétique)</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Polymorphisme de nucléotide simple</term><term>Pression intraoculaire (génétique)</term><term>Prédisposition génétique à une maladie (génétique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Système ABO de groupes sanguins (génétique)</term><term>Transporteur-1 à cassette liant l'ATP (génétique)</term><term>Étude d'association pangénomique</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>ABO Blood-Group System</term><term>ATP Binding Cassette Transporter 1</term><term>Fibronectins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 11</term><term>Chromosomes, Human, Pair 3</term><term>Chromosomes, Human, Pair 9</term><term>Genetic Loci</term><term>Genetic Predisposition to Disease</term><term>Glaucoma</term><term>Glaucoma, Open-Angle</term><term>Intraocular Pressure</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes humains de la paire 11</term><term>Chromosomes humains de la paire 3</term><term>Chromosomes humains de la paire 9</term><term>Fibronectines</term><term>Glaucome</term><term>Glaucome à angle ouvert</term><term>Locus génétiques</term><term>Pression intraoculaire</term><term>Prédisposition génétique à une maladie</term><term>Système ABO de groupes sanguins</term><term>Transporteur-1 à cassette liant l'ATP</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Polymorphisme de nucléotide simple</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Étude d'association pangénomique</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma and IOP variability may herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multiethnic participants for IOP. We confirm genetic association of known loci for IOP and primary open angle glaucoma (POAG) and identify four new IOP loci located on chromosome 3q25.31 within the <italic>FNDC3B</italic> gene (p=4.19×10<sup>−08</sup> for rs6445055), two on chromosome 9 (p=2.80×10<sup>−11</sup> for rs2472493 near <italic>ABCA1</italic> and p=6.39×10<sup>−11</sup> for rs8176693 within <italic>ABO</italic>) and one on chromosome 11p11.2 (best p=1.04×10<sup>−11</sup> for rs747782). Separate meta-analyses of four independent POAG cohorts, totaling 4,284 cases and 95,560 controls, show that three of these IOP loci are also associated with POAG.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Quigley, Ha" uniqKey="Quigley H">HA Quigley</name></author><author><name sortKey="Broman, At" uniqKey="Broman A">AT Broman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heijl, A" uniqKey="Heijl A">A Heijl</name></author><author><name sortKey="Leske, Mc" uniqKey="Leske M">MC Leske</name></author><author><name sortKey="Bengtsson, B" uniqKey="Bengtsson B">B Bengtsson</name></author><author><name sortKey="Hyman, L" uniqKey="Hyman L">L Hyman</name></author><author><name sortKey="Hussein, M" uniqKey="Hussein M">M Hussein</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kass, Ma" uniqKey="Kass M">MA 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(État)</li><li>Écosse</li></region><settlement><li>Amsterdam</li><li>Bordeaux</li><li>Leyde</li><li>Lille</li><li>Londres</li><li>Mayence</li><li>Melbourne</li><li>Rotterdam</li><li>Édimbourg</li></settlement><orgName><li>University College de Londres</li><li>Université Lille 2</li><li>Université de Melbourne</li><li>Université nationale de Singapour</li></orgName></list><tree><noCountry><name sortKey="Cuellar Partida, Gabriel" sort="Cuellar Partida, Gabriel" uniqKey="Cuellar Partida G" first="Gabriel" last="Cuellar-Partida">Gabriel Cuellar-Partida</name><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name></noRegion><name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name><name sortKey="Fleck, Brian W" sort="Fleck, Brian W" uniqKey="Fleck B" first="Brian W" last="Fleck">Brian W. Fleck</name><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name><name sortKey="Kirwan, James" sort="Kirwan, James" uniqKey="Kirwan J" first="James" last="Kirwan">James Kirwan</name><name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name><name sortKey="Nag, Abhishek" sort="Nag, Abhishek" uniqKey="Nag A" first="Abhishek" last="Nag">Abhishek Nag</name><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S" last="Small">Kerrin S. Small</name><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><name sortKey="Viswanathan, Ananth" sort="Viswanathan, Ananth" uniqKey="Viswanathan A" first="Ananth" last="Viswanathan">Ananth Viswanathan</name><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name></country><country name="Singapour"><noRegion><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name></noRegion><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><name sortKey="Liao, Jiemin" sort="Liao, Jiemin" uniqKey="Liao J" first="Jiemin" last="Liao">Jiemin Liao</name><name sortKey="Liao, Jiemin" sort="Liao, Jiemin" uniqKey="Liao J" first="Jiemin" last="Liao">Jiemin Liao</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><name sortKey="Zheng, Yingfeng" sort="Zheng, Yingfeng" uniqKey="Zheng Y" first="Yingfeng" last="Zheng">Yingfeng Zheng</name><name sortKey="Zheng, Yingfeng" sort="Zheng, Yingfeng" uniqKey="Zheng Y" first="Yingfeng" last="Zheng">Yingfeng Zheng</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Springelkamp, Henriet" sort="Springelkamp, Henriet" uniqKey="Springelkamp H" first="Henriët" last="Springelkamp">Henriët Springelkamp</name></region><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><name sortKey="De Jong, Paulus T V M" sort="De Jong, Paulus T V M" uniqKey="De Jong P" first="Paulus T. 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Stefansson</name><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name></region><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><name sortKey="Delcourt, Cecile" sort="Delcourt, Cecile" uniqKey="Delcourt C" first="Cécile" last="Delcourt">Cécile Delcourt</name><name sortKey="Delcourt, Cecile" sort="Delcourt, Cecile" uniqKey="Delcourt C" first="Cécile" last="Delcourt">Cécile Delcourt</name><name sortKey="Maubaret, Cecilia" sort="Maubaret, Cecilia" uniqKey="Maubaret C" first="Cécilia" last="Maubaret">Cécilia Maubaret</name><name sortKey="Maubaret, Cecilia" sort="Maubaret, Cecilia" uniqKey="Maubaret C" first="Cécilia" last="Maubaret">Cécilia Maubaret</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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